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Allergic Reactions to Drugs (Paperback, Softcover reprint of the original 1st ed. 1983)
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Allergic Reactions to Drugs (Paperback, Softcover reprint of the original 1st ed. 1983)
Series: Handbook of Experimental Pharmacology, 63
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According to most studies, allergic reactions represent 35%-50% of
all untoward reactions to drugs, yet the pharmacological literature
concerning the clinical aspects, diagnosis, and pathophysiological
mechanisms of drug allergy is markedly less extensive than reports
dealing with the toxicological or pharmacological effects of drugs.
The main reasons for this state of affairs may be on the one hand
that until a few years ago the pathophysiological mechanisms of the
various types of allergic reactions were not well understood, and
on the other hand that objective diagnosis of a drug allergy is
still fraught with serious difficulties. Drug allergy is still an
unpopular topic for most allergologists and pharmacologists; this
is reflected by the fact that despite their frequency, allergic
reactions to drugs still occupy a relatively small proportion of
space in most pharmacology handbooks and in classical books devoted
to the side effects of drugs. There has recently been considerable
progress in research into the immunologi cal and pathophysiological
events occurring in allergic reactions, and on that basis
investigations of various drug allergies have also yield d new
objective findings. Consequently, it was natural to attempt a
review of the most frequent and important drug allergies in the
form of a handbook. We originally intended to present a
comprehensive review of all drug allergies, but the realization of
this goal soon became more difficult than we had at first
imagined."
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