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Books > Medicine > Other branches of medicine > Psychiatry
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Analysis of Psychiatric Drugs (Hardcover, 1989 ed.)
Loot Price: R4,331
Discovery Miles 43 310
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Analysis of Psychiatric Drugs (Hardcover, 1989 ed.)
Series: Neuromethods, 10
Expected to ship within 10 - 15 working days
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In this volume, we hope to cover the malor techniques that are
presently being used to analyze the actions of drugs used in psyc-
atry. The contributors of the chapters are active researchers who
have considerable practical experience with the techniques they are
describing, and the emphasis in the chapters is on three types of
psychiatric drugs, namely antidepressants, antipsychotics, and
anxiolytics. The first chapter, by Curry and Yu, discusses protein
binding of psychotropic drugs, with special reference to
equilibrium ana- sis as the method of assessment and to
lipophilicity correlations. Since many of the drugs used in
treating psychiatric disorders are bound extensively to protein,
this aspect is of great importance with regard to their therapeutic
actions and toxicity, Basic mat- matical models, techniques for the
study of protein binding, molecular aspects of protein binding,
binding in relation to lipophilicity, indirect approaches to
measurement of the fraction of drug bound, the function of protein
binding, and tissue binding are among the topics discussed. Chapter
2, by Norman and B- rows, deals with the principles of isotope
derivative assays and their applications to antidepressants and
antipsychotics; extensive protocols are provided. The third
chapter, by Cooper, deals with analysis by gas-liquid
chromatography. Sample collection and storage, extraction
procedures, column selection, use of internal standards, types of
detectors, techniques of application, and - plications to specific
drugs are among the topics discussed.
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