Recent research, especially in fields of orthopaedic surgery and
rehabilita tion, point to the importance of periodic, moderate
stress for maintaining normal structure and function of tissues.
Moreover, growth and healing of load-bearing tissues such as bone,
cartilage, and intervertebral disc are especially dependent upon
stress-related stimuli. Extreme levels of stress, however, are
usually detrimental to tissue integrity, and most treatment
regimens today address problems related to trauma and other
conditions of abnormally high stress. Therefore, the purpose of
this book is to bring together experts in fields of tissue
nutrition and growth in order to review previous work and examine
new ideas and results concerning the importance of mechanical
stress in tissues. This book is unique in that the topic of tissue
nutrition and growth, especially related to possible benefits of
periodic moderate stress, has never been addressed comprehensively,
drawing together experts on vari ous tissues and organs. One
objective is to focus attention on tissue nutrition where
controversy still exists regarding basic mechanisms of metabolite
transport and fluid homeostasis within the interstitium. An other
objective is to examine the pathophysiology of tissue compression
and discuss strategies to improve viability. Tissues which are
treated in this book include bone, cartilage, intervertebral disc,
lung, nerve, skeletal muscle, umbilical cord, synovium, skin, and
subcutaneous tissues. Based upon these objectives, this book is
primarily addressed to students, inves tigators, and teachers in
fields of physiology, biochemistry, biomechan ics, exercise,
orthopaedic surgery, rehabilitation, and sports medicine."
General
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