Computational Methods for GPCR Drug Discovery (Hardcover, 1st ed. 2018)

This volume looks at modern computational strategies and techniques used in GPCR drug discovery including structure and ligand-based approaches and cheminformatics. The chapters in this book describe how these approaches can be applied to address key drug discovery issues, such as receptor structure modelling, function and dynamics, prediction of protein-water-ligand interactions and binding kinetics, free energy of binding, interconversion between agonists and antagonists, deorphanization of GPCRs, and the discovery of biased and allosteric modulators. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary software and tools, step-by-step, readily reproducible modelling protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and unique,Computational Methods for GPCR Drug Discovery is a valuable resource for structural and molecular biologists, computational and medicinal chemists, pharmacologists, and drug designers.

General

Imprint:	HumanaPress
Country of origin:	United States
Series:	Methods in Molecular Biology, 1705
Release date:	December 2017
First published:	2018
Editors:	Alexander Heifetz
Dimensions:	254 x 178mm (L x W)
Format:	Hardcover
Pages:	436
Edition:	1st ed. 2018
ISBN-13:	978-1-4939-7464-1
Categories:	Books > Medicine > Other branches of medicine > Pharmacology > General
LSN:	1-4939-7464-5
Barcode:	9781493974641

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