Structural genomics is the systematic determination of 3-D
structures of proteins representative of the range of protein
structure and function found in nature. The goal is to build a body
of structural information that will predict the structure and
potential function for almost any protein from knowledge of its
coding sequence. This is essential information for understanding
the functioning of the human proteome, the ensemble of tens of
thousands of proteins specified by the human genome.
While most structural biologists pursue structures of individual
proteins or protein groups, specialists in structural genomics
pursue structures of proteins on a genome wide scale. This implies
large-scale cloning, expression and purification. One main
advantage of this approach is economy of scale.
Key Features
*Examines the three dimensional structure of all proteins of a
given organism, by experimental methods such as X-ray
crystallography and NMR spectroscopy
* Looks at structural genomics as a foundation of drug discovery as
discovering new medicines is becoming more challenging and the
pharmaceutical industry is looking to new technologies to help in
this mission
General
| Imprint: |
Academic Press Inc
|
| Country of origin: |
United States |
| Series: |
Advances in Protein Chemistry and Structural Biology |
| Release date: |
September 2010 |
| First published: |
August 2010 |
| Authors: |
Alexander McPherson
|
| Dimensions: |
229 x 152 x 18mm (L x W x T) |
| Format: |
Hardcover - Cloth over boards
|
| Pages: |
240 |
| Edition: |
79th edition |
| ISBN-13: |
978-0-12-381278-0 |
| Categories: |
Books >
Science & Mathematics >
Biology, life sciences >
Biochemistry >
Proteins
|
| LSN: |
0-12-381278-X |
| Barcode: |
9780123812780 |
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