Books > Medicine > Pre-clinical medicine: basic sciences > Physiology
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Multiple Sclerosis - An Overview of Clinical Features, Pathophysiology, Neuroimaging, and Treatment Options (Paperback)
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Multiple Sclerosis - An Overview of Clinical Features, Pathophysiology, Neuroimaging, and Treatment Options (Paperback)
Series: Colloquium Series on Integrated Systems Physiology: From Molecule to Function
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Multiple sclerosis [MS] is one of the most common
auto-immune-mediated diseases of the human central nervous system
[CNS] which affects young adults and usually causes significant
neurological disability. Currently, the causes of MS are still
unclear, a cure for MS remains elusive and the effectiveness of
treatment varies significantly among individuals. Clinical features
and neurological deficits stemming from this progressive
neurological disease are diverse since MS potentially affects human
CNS at all levels from brain to the end of spinal cord. The
triggering event for development of MS remains unknown.
Immunopathogenesis of MS involves a number of steps which include
activation of peripheral leukocytes against putative CNS
antigen(s), interactions of the activated leukocytes with inflamed
cerebral endothelial cells, transendothelial migration of activated
lymphocytes and macrophages to the CNS milieu, and further
propagation of the massive immune response within the CNS. Such
massive immune activation leads to loss of myelin-oligodendrocyte
complex. Several immune cell types and mediators of the
immune-inflammatory response actively contribute to pathogenesis of
MS. Genetic factors are also believed to play a central role in the
development of most forms of MS. Another important but much
unrecognized and under-researched feature of MS immunopathology is
"neurodegeneration." Neuronal loss and axonal degeneration are the
core components of irreversible and permanent CNS atrophy and
disability in MS. What we call MS in reality is a heterogeneous
group of diseases and at least four distinct immunopathological
subtypes of MS with dissimilar responses to therapy with
immunomodulatory agents exist. MS is a clinical diagnosis, however,
its diagnostic process is much facilitated by utilization of
laboratory and neuroimaging studies. Present therapies of MS are
either immunomodulatory agents or immunosuppressive and mainly
target the peripheral immune system with the intention to
ameliorate the severity of acute relapses, decrease annual relapse
rate, and improve MRI lesions. Currently, much research activity is
being conducted to better understand the fundamental disease
mechanisms of MS and find more effective and safer treatments for
this incurable disease. This book presents an overview of MS as a
disease with neuroinflammatory and neurodegenerative features and
the authors discuss the most recent findings about MS and its
treatment.
General
Imprint: |
Morgan & Claypool Publishers
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Country of origin: |
United States |
Series: |
Colloquium Series on Integrated Systems Physiology: From Molecule to Function |
Release date: |
September 2014 |
Authors: |
Alireza Minagar
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Dimensions: |
235 x 191 x 6mm (L x W x T) |
Format: |
Paperback
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Pages: |
117 |
ISBN-13: |
978-1-61504-588-4 |
Categories: |
Books >
Medicine >
Pre-clinical medicine: basic sciences >
Physiology >
General
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LSN: |
1-61504-588-0 |
Barcode: |
9781615045884 |
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