Somatostatins (SST) form a family of cyclopeptides that are mainly
produced by normal endocrine, gastrointestinal, immune and neuronal
cells, as well as by certain tumours. By binding to
G-protein-coupled receptors on target cells, SST act as
neuromodulators and neurotransmitters, as well as potent inhibitors
of various secretory processes and cell proliferation. In this
book, the authors discuss the synthesis, mechanisms-of-action and
physiological effects of somatostatins. Topics include the effects
of somatostatin in animal models of retinal disease; radiolabelled
somatostatin analogues for use in molecular imaging; somatostain
analogs as a treatment for congenital hyperinsulinism; somatostain
and its receptors in the mammalian cochlea; diagnostic accuracy of
positron emission tomography with somatostatin analogues in
gastroenteropancreatic and thoracic neuroendocrine tumours.
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