4-Thiazolidinones are one of the emerging classes of heterocyclic
privileged scaffold. Because of their biological importance,
several methods have been developed for the synthesis of
4-thiazolidinone skeleton. The only method reported for solid phase
synthesis of 4-thiazolidinones is by C. P. Holmes. A careful survey
of the literature revealed that solid-phase synthesis of
4-thiazolidinone with a suitable methodology has not been reported
yet. The challenge is to develop a solid phase methodology that
affords fast and easy generation of combinatorial library of
4-thiazolidinones, with high yield and appropriate diversity. There
are three major points for diversification in 4-thiazolidinone
scaffold pointed out providing an opportunity to explore different
substituent at these positions. Therefore, the present study makes
an effort towards the synthesis of a library of 4-thiazolidinones
and 4-metathiazanones with suitable diversity at one, two or three
points with the use of suitable coupling agents and other reagents.
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