Diabetes mellitus is a group of metabolic diseases characterized by
hyperglycemia resulting from defects in insulin secretion, insulin
action, or both. Here we focused on the epidemiology, late diabetic
complications, association between diabetes mellitus and HCV
infection and plasma protein profiling. Type 2 diabetes is most
prevalent type and is more common in females. Above 70% diabetics
had poor glycemic control along with one or more late diabetic
complication(s) i.e. hypertensions, any grade of retinopathy and
neuropathy. About 36.538% diabetic patients were reported to have
HCV infection while in control group only 1.923% subjects were HCV
positive by RT-PCR. Female diabetics have more risk to acquire HCV
as compare to the male diabetic patients. Medical practices
(hospitalization) play no role in nosocomial transmission of HCV in
diabetic patients. Differences in the protein pattern were observed
in low molecular weight proteins (5 to 35 kDa). Protein bands of
31kDa, 11kDa and 6.5kDa were missing in some diabetic HCV positive
samples. Plasma protein profiling of diabetic patients by SDS-PAGE
may be helpful to evaluate the disease state.
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