This book is a collection of some of the papers presented at the
EMBO Lecture Course on "Lymphocyte stimulation: differential
sensitivity to radiation; biochemical and immunological
properties." The Course was organized with the aim of fostering
interactions between photoradiobiologists and immunologists
interested in the problem of DNA damage and repair studied at the
lymphocyte level. The papers presented in this book are mainly
centered on the problem of radiation sensitivity of lymphocytes in
relation to DNA repair phenomena. The radiation biology of human
lymphocytes is dominated by two phenomena: (a) high
radiosensitivity of lymphocytes which die in interphase (b)
PHA-induced relative radioresistance of those cells which, after
stimulation, escape the interphase death and eventually die in
mitosis. These phenomena constitute a good system to study some of
the factors which control the response of human cells to
irradiation. In addition it is possible to correlate the
development of the relative radioresistance in PHA-stimulated
lymphocytes with the biochemical changes connected with the
transformation processes. The papers presented in this book
constitute a real contribution to the scientific knowledge in this
field of research and suggest that lymphocytes could be a very
interesting test material useful for measuring the DNA repair
capability of human cells to furnish an indication of individual
radiosensitivity in man.
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