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Pharmacology of Endogenous Neurotoxins - A Handbook (Paperback, Softcover reprint of the original 1st ed. 1998)
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Discovery Miles 16 200
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Pharmacology of Endogenous Neurotoxins - A Handbook (Paperback, Softcover reprint of the original 1st ed. 1998)
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It is a great pleasure to write the foreword to this important
volume for several reasons. First: As far as we know, already
primitive societies had to cope with environmental toxins of many
kinds and set up regulations to limit their effects on food and
drug use. Modem science, synthesizing tens of millions of new
compounds has incredibly magnified this challenge. Today,
xenobiotic metabolism has become a crucial task for humans and many
other species alike. Second: When reading this book, one is
impressed by the extraordinary speed at which neurotoxicology has
advanced. Obviously, processing (and endogenous formation) oftox
ins has become an extremely relevant topic. When I had the chance,
almost three decades ago, to work in chemical pharmacology with
Bernard B. Brodie at NIH, the drug metabo lizing system of the
liver had just been recognized and characterized. We had just
started to work on the biogenic amines, newly discovered cyclic
nucleotides in rat brain, human cere brospinal fluid, and on the
effects of toxic drugs like amphetamines. Today, biochemical
neuropharmacology is a mature field of neuroscience."
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