Since the first recognition of outbreaks of cerebrospinal or
spotted fever at the end of the nineteenth and the beginning of the
twentieth centuries, the menace of the meningococcus has been high
on the list of public health prio- ties. Few if any pathogens
surpass the meningococcus in the rapidity and sev- ity with which
it devastates previously healthy individuals. The challenge of
understanding the biology of this fascinating microbe is immense,
but few will doubt that successful control of meningococcal
meningitis and septicemia will only transpire through the
application of a body of extraordinary detailed inf- mation,
including key minutiae of its molecular biology. In the first of
two companion volumes, Meningococcal Vaccines, the team of experts
gathered by Andy Pollard and Martin Maiden converge to p- vide an
impressive accumulation of molecular tools with which to lay bare
the secrets of the meningococcus. The results of this ambitious and
welcome v- ume represent an exciting and much needed resource for
all of us in the field.
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