Knowledge about protein tertiary structure can guide experiments,
assist in the understanding of structure-function relationships,
and aid the design of new therapeutics for disease. Homology
modeling is an in silico method that predicts the tertiary
structure of an amino acid sequence based on a homologous
experimentally determined structure. In, Homology Modelling:
Methods and Protocols experts in the field describe each homology
modeling step from first principles, provide case studies for
challenging modeling targets and describe methods for the
prediction of how other molecules such as drugs can interact with
the protein. Written in the highly successful Methods in Molecular
Biology (TM) series format, the chapters include the kind of
detailed description and implementation advice that is crucial for
getting optimal results in the laboratory. Thorough and intuitive,
Homology Modelling: Methods and Protocols guides scientists in the
available homology modeling methods.
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