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Studies on Psychiatric Disorders (Hardcover, 2015 ed.)
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Studies on Psychiatric Disorders (Hardcover, 2015 ed.)
Series: Oxidative Stress in Applied Basic Research and Clinical Practice
Expected to ship within 12 - 17 working days
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This authoritative volume reviews clinical, pathophysiological and
therapeutic aspects of oxidative and nitrosative stress in
different psychiatric disorders such as schizophrenia, bipolar
disorder, autism, and attention deficit hyperactivity disorder
(ADHD). Twenty-nine comprehensive chapters are divided into three
distinct sections: clinical aspects, pathophysiological aspects,
and therapeutic aspects. Together, these chapters present the
environmental, genetic and neurodevelopmental factors in the
generation of oxidative stress in psychiatric disorders, with
particular emphasis on the biochemical changes associated with
oxidative stress in dopaminergic and glutamate neurotransmission as
well as mitochondrial dysfunction in the brain and peripheral
cells. Through an investigation of glutamic acid decarboxylase
(GAD) abnormalities in schizophrenia, the book provides a coherent
framework to account for the impact of oxidative stress on
pathological phenomena ranging from cellular to cognitive and
clinical aspects. It describes biomarkers of oxidative damage, the
role of oxidative stress in numerous abnormalities of biochemical
pathways in the pathophysiology of schizophrenia, the development
of new investigative techniques, specially neuroimaging, and
studies of apoptotic pathways that seem to prove neurodegenerative
and neurodevelopmental theories. Written by leading researchers in
their fields, Studies on Psychiatric Disorders explores therapeutic
approaches with aspects of various antioxidants, cryostimulation,
and hyperbaric oxygen treatment in oxidative stress in
neuropsychiatric diseases. The volume also discusses the role of
antipsychotics in the treatment of schizophrenia on nitric oxide
generation and biomarkers of oxidative stress together with the
clinical symptomatology. Overall, it proposes that novel
therapeutic strategies such as supplementation with antioxidants-in
particular polyphenols, -3 fatty acids or combination of both-could
be effective for long-term treatment of some neuropsychiatric
disorders.
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