Mitochondrial Medicine is a relatively new area where several
disciplines from basic science to clinical medicine converge.
Mitochondrial medicine deals with diseases that are related to
mitochondrial dysfunction due to a number of causes from free
radical damage to genetic mutation. A primary feature of
mitochondrial dysfunction is impaired cellular bioenergetics.
This book is based upon extensive data gathered over 30 years of
clinical and experimental research. Internationally recognized
authors share their experience and state-of-the-art knowledge in
various fields of their expertise such as mitochondrial cardiology,
neurology, diabetology, nephrology, immunology, rheumatology,
reproductive medicine, sports medicine, and chronobiology, and
guide readers through the disease process, from basic biochemical
mechanisms to diagnosis to therapeutic aspects.
Laboratory evaluation plays a very important role in the
diagnosis of mitochondrial diseases, in addition to clinical
assessment. This includes analysis of plasma/mitochondrial coenzyme
Q10 content, mitochondrial respiratory chain function and oxidative
phosphorylation in isolated mitochondria and biopsy material, and
nuclear magnetic resonance methods.
In addition to standard medical therapy to treat cardiac, CNS,
and other involvements in the mitochondrial disease patients,
adjunctive nutritional therapy is indicated primarily to improve
mitochondrial function. Therapy include coenzyme Q10, a -lipoic
acid, carnitine, w -3- and w -6-PUFA, vitamins and polarized
light.
Mitochondrial Medicine is dedicated to Dr. Frederick L. Crane,
discoverer of Coenzyme Q10 in 1957, and to the Celebration of 50th
year of Coenzyme Q10discovery.
This book is intended for general medical practitioners, for
specialists specialists such as cardiologists, neurologists, and
diabetologists, biochemists, nutritionists, pharmacists, and also
for graduate students.
General
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