The purpose of this research was to formulate tasteless complexes
of Fexofenadine Hydrochloride with Kyron-134 and to formulate
tasteless complex into fast-Dispersible tablets (FDT) for the
treatment of allergic rhinitis & chronic idiopathic urticaria.
Drug release from FDT in salivary pH was insufficient to impart
bitter taste. Complete drug release was observed at gastric pH. The
studies indicate that the formulation was taste masked drug can be
formulated in to FDT with view to enhance patient compliance &
to obtain faster onset action of the drug which would be
advantageous in comparison to the currently available conventional
forms. Formulations D-5 was found to be palatable with in vitro
disintegration time of 20 s Dissolution studies showed complete
release of D-5 within 30 min.
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