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Formulation and Evaluation of Colon Targeted Aceclofenac Tablet (Paperback)
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Discovery Miles 13 170
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Formulation and Evaluation of Colon Targeted Aceclofenac Tablet (Paperback)
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The aim of the study was to develop and evaluate enteric coated
matrix tablet of Aceclofenac for colonic delivery by exploiting
prolonged release characteristics of HPMC K4M with pH dependent
solubility property of a Eudragit S100. Extended release matrix
tablet were prepared by direct compression of hydrophilic polymer
HPMC and other ingredients. The pH dependent release was achieved
by coating matrix tablet with Eudragit S100, soluble at pH 7. All
the formulations of 32 factorial design (A1- A9) were evaluated for
the physicochemical parameters and subjected to in vitro drug
release in 0.1 N HCl for two hour, three hour in pH 5.2 Phosphate
buffer then in pH 7.4 phosphate buffer up to 17 hrs. Multiple
regression analysis, two way ANOVA followed by Tukey test were
performed. Polynomial equations and response surface plots were
generated for all dependent variables. It was observed that both
the factors had significant effect on dependable variables (Q6,
Q12, Q17 and n, k). The formulation A5 was most likely to provide
targeting of aceclofenac in the colon owing to its minimal release
of the drug in the first 5 hr and give release up to 17hr with
62.21 similarity factor."
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