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Development and Validation of Periodontal in Situ Gel of Articaine (Paperback)
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Development and Validation of Periodontal in Situ Gel of Articaine (Paperback)
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Articaine hydrochloride, a water soluble local anesthetic, is
administered by block/infiltration anesthesia during the treatment
of periodontitis. The pain, associated with injection of local
anesthetics, can be overcome by the use of in situ gel forming
system of local anesthetics. The system is a low viscosity fluid at
room temperature and rigid elastic gel at body temperature,
undergoing in situ sol gel transition.The present work describes
the formulation, characterization and preliminary drug release
studies of muco-adhesive formulations containing articaine,
polaxomer 407 as the thermoreversible gelling agent in combination
with hydroxypropylmethylcellulose (HPMC) and Carbopol 934P, as a
muco-adhesive agent. Each formulation was characterized in terms of
gelling temperature, viscosity, muco-adhesive force, spreadability,
drug release.The gelling temperature varied with the polymer
concentration and the presence of drug.The in vitro and ex vitro
permeation studies indicated the sustained drug release for a 7-h
period.Prospective Process Validation was also performed on
formulations.The developed system is a viable alternative for the
conventional injectable dosage form.
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