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Phytochemical and Biological Investigations of Thunbergia Grandiflora (Paperback)
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Phytochemical and Biological Investigations of Thunbergia Grandiflora (Paperback)
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Thunbergia grandiflora(Acanthaceae) has been investigated for
isolation of its secondary metabolites and evaluation of biological
activities of the crude extractive. One compound had been isolated,
which was identified by extensive analyses of resolution NMR
spectral data. The powdered leaf of T. grandiflora was extracted
separately with methanol. The solid extract was then subjected to
vacuum liquid chromatography (VLC). Repeated chromatographic
separation and purification the leaves of Thunbergia grandiflora
afforded one flavonoid named 5 hydroxy-4',6,7- trimethoxy flavone,
C18H16O6. The Methanolic crude extract of Thunbergia grandiflora
showed moderate analgesic activity. Out of all the samples only
chloroform fraction methanolic crude extract were appeared mild
potent in terms of both zone of inhibition & spectrum of
activity against some gram positive, gram negative bacteria and
fungi. In antidiarrhoeal test and brine shrimp lethality bioassay,
hexane, carbon tetrachloride, chloroform and aqueous fractions
exhibited insignificant activities whereas Carbon tetra chloride
fraction showed some hypoglycemic effect at a dose of 300 mg/kg
body weight compared to control group.
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