For over 20 years I have accepted the challenge and had the
privilege of caring for sick children, agonizing with their parents
during periods of serious illness, which were sometimes fatal.
Because of my particular interest in and concern about birth
defects and genetic disease, many of these children had severe
disabling handicaps, which were often genetic and included mental
retardation. Hence care of these children and their families was
often complicated by the presence of serious or profound genetic
defects. The initial realization of the nature of the disorder
invariably led to emotional . difficulties and inevitably later
spawned chronic distress. For some children inexorable
deterioration led to untimely deaths, while the parents agonized
over their handi capped, chronically ill, or defective-but
nevertheless loved---"
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