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Books > Medicine > Clinical & internal medicine > Endocrinology
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Graves' Disease - Pathogenesis and Treatment (Hardcover, 2000 ed.)
Loot Price: R4,181
Discovery Miles 41 810
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Graves' Disease - Pathogenesis and Treatment (Hardcover, 2000 ed.)
Series: Endocrine Updates, 6
Expected to ship within 10 - 15 working days
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From the perspective of the investigator, Graves' disease is a
fascinating disorder with unique features and opportunities for
study. The discovery in 1956 that Graves' disease was caused by a
humoral factor, later shown to be an antibody to the TSH receptor,
was a triumph for modern investigative medicine. Rapid progress is
now being made in (i) understanding the molecular interaction
between autoantibodies and the TSH receptor, (ii) identifying the
genes that contribute to the predisposition to disease, (iii)
developing an animal model of Graves' disease, and (iv) identifying
the long-sought orbital antigen in ophthalmopathy. From the
clinical standpoint, although Graves' disease is eminently
treatable, there is no definitive cure. None of the therapeutic
options are ideal. It is hoped that rapid progress in understanding
the pathogenesis of the disease will lead to the ultimate goal of
some form of immunotherapy that will make antithyroid drugs,
radioiodine and thyroidectomy obsolete. The chapters in Graves'
Disease: Pathogenesis and Treatment represent the viewpoints of
many prominent clinicians and investigators working in the field.
The editors are grateful for their contributions which cover an
unusually comprehensive compendium of subjects relating to the
disease.
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