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Rethinking Cancer - A New Paradigm for the Postgenomics Era (Hardcover)
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Rethinking Cancer - A New Paradigm for the Postgenomics Era (Hardcover)
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Leading scientists argue for a new paradigm for cancer research,
proposing a complex systems view of cancer supported by empirical
evidence. Current consensus in cancer research explains cancer as a
disease caused by specific mutations in certain genes. After
dramatic advances in genome sequencing, never before have we known
so much about the individual cancer cell--and yet never before has
it been so unclear what to do with this knowledge. In this volume,
leading researchers argue for a new theory framework for
understanding and treating cancer. The contributors propose a
complex systems view of cancer, presenting conceptual building
blocks for a new research paradigm supported by empirical evidence.
The contributors first discuss the new research framework in terms
of theoretical foundations and then take up the relevance of a
systems approach, reviewing such topics as nonlinearity, recurrence
after treatment, the cellular attractor concept, network theory,
and non-coding DNA--the dark matter of our genome. They address the
temporality of cancer progression, drawing on evolutionary theory
and clinical experience. Finally, they cover the dominant role of
the tissue microenvironment in cancer, analyzing topics including
altered metabolic pathways, the disease-defining influence on
metastasis, and the interconnectedness of different environmental
niches across levels of organization.
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