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Books > Medicine > Pre-clinical medicine: basic sciences > Medical genetics
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DNA Damage and Repair in Human Tissues (Paperback, Softcover reprint of the original 1st ed. 1990)
Loot Price: R1,573
Discovery Miles 15 730
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DNA Damage and Repair in Human Tissues (Paperback, Softcover reprint of the original 1st ed. 1990)
Series: Basic Life Sciences, 53
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Physical and chemical agents in the environment damage the DNA of
humans, and pose a major threat to human health today, and to the
genetic integrity of human populations. Although studies on
isolated DNA in vitro, on prokaryotes, on mammalian cells in
culture, and on laboratory animals have provided essential
background information, it is now possible to study DNA damage and
repair in human tissues directly. New techniques of high
sensitivity, especially those not requiring radioactive labeling
have made possible quantitation of DNA damage and repair, as well
as detection of residual, unrepaired DNA lesions . In recent years,
several investigators have taken up the challenge of studying
damage and repair responses in humans, and we have chosen that work
as the special focus of this Symposium. Major advances in under
standing damage and responses in human skin, in blood cells and in
human internal organs indicate three major themes. First, DNA
damage levels in human tissues depend not only on the initial
exposures, but also on the capapacity of that tissue for repair of
the specific lesion type. Second, repair in human tissues may
differ quantitatively and qualitatively from that in human cells in
culture.
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