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Books > Medicine > Clinical & internal medicine > Cardiovascular medicine
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Subcellular Basis of Contractile Failure - Proceedings of the Symposium Sponsored by the Council of Cardiac Metabolism, International Society and Federation of Cardiology and International Society for Heart Research, May 11-13, 1989, Ottawa, Canada (Hardcover, 1990 ed.)
Loot Price: R4,334
Discovery Miles 43 340
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Subcellular Basis of Contractile Failure - Proceedings of the Symposium Sponsored by the Council of Cardiac Metabolism, International Society and Federation of Cardiology and International Society for Heart Research, May 11-13, 1989, Ottawa, Canada (Hardcover, 1990 ed.)
Series: Developments in Cardiovascular Medicine, 116
Expected to ship within 12 - 17 working days
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This monograph contains 20 selected papers presented at the
Symposium on Subcellular Basis of Contractile Failure which was
held in Ottawa during May 11-13, 1989 and is designed for the
benefit ofthose who were unable to attend this event. It is now
increasingly becoming clear that an excessive amount of calcium is
intimately involved in the pathogenesis of a wide variety of heart
diseases. Accordingly, the investigations concerning the role of
calcium chan nels and their regulatory mechanisms in heart function
as well as of the intra cellular calcium overload in cardiac
dysfunction are presented here. Since sodium is also considered to
influence the cardiac contractile force by chang 2 ing the
intracellular concentration of calcium through the Na +-Ca+
exchange 2 mechanism in the cell membrane, the role of Na +-Ca+
exchange in heart func tion as well as pathology of contractile
failure is discussed. In view of the new ly discovered implications
of the oxygen free radicals in cellular injury, papers concerning
the role of these radicals in heart disease are included in this
book. For the purpose of clarity, different chapters have been
organized under three main headings: (I) Role of cations in heart
function, (II) Cardiac hypertrophy and cardiomyopathies, and (III)
Ischemic heart disease and cardiac failure."
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