Normal and diabetic patients with different age and gender were
selected from human population pertaining to rural background for
investigation homocysteine (Hcy) and DNA damage as biomarkers.
Normally with age, ESR, glycosylated haemoglobin, glucose,
cholesterol, triglyceride, HDL, LDL, total proteins, albumin,
globulins, creatinine, urea, ALT and AST did increase while PCV, Hb
did decrease significantly. Health markers (SOD, GPx, Hcy, sialic
acid and hexosamine) did increase significantly. Diabetic patients
did show a significant increase in their ESR, glycosylated Hb,
glycosylated proteins, glucose, cholesterol, triglycerides, total
proteins, albumin, creatinine, urea, ALT, AST, SOD, GPx, Hcy, K and
Fe concentration, however, PCV, Hb, vitamin C, E, A, T3, T4, Na,
Ca, Mg, Zn and Se did decrease significantly. DNA damage was
negatively correlated with Hb, vitamin C, E, A, T3 and T4.
Homocysteine was positively co-related with systolic blood
pressure, ESR, glycosylated Hb and proteins, glucose, cholesterol,
triglyceride, albumin, creatinine, urea, ALT, AST, superoxide
dismutase, sialic acid, hexosamine, testosterone, sodium, potassium
and magnesium
General
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