Mitochondria are complex organelles, possessing a
double-membrane and even their own genome, the mtDNA. They play a
pivotal role in cellular metabolism, respiration, and production of
ATP essential for the normal function of all human organ systems.
It is not surprising, therefore, that genetic defects of
mitochondrial functions cause a wide spectrum of human diseases.
This book provides the first modern and truly comprehensive
coverage of the biochemistry, genetics, and pathology of
mitochondria in different organisms. It particularly focuses on the
recent advances in our understanding of basic mitochondrial
research to the consequences of dysfunction at the molecular
level.
The 13 contributions written by leading researchers in the field
include topics such as: mitochondrial genome evolution and mtDNA
stability, mitochondrial biogenesis and protein quality control,
mitochondrial morphology, assembly and function of the
mitochondrial energy generation apparatus and mitochondrial
metabolic pathways. These are particularly oriented to link in
these various mitochondrial pathways to the clinical consequences
of their dysfunctions.
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