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Drug Delivery in Dermatology - Fundamental and Practical Applications (Hardcover, 1st ed. 2021)
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Drug Delivery in Dermatology - Fundamental and Practical Applications (Hardcover, 1st ed. 2021)
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Skin accounts for approximately 15% of an adult's total body
weight, with a surface of about 2m(2). It provides an entry and
exit barrier to various substances, offers effective protection
against harmful substances, microorganisms and ultraviolet
radiation, and is also paramount in immunology and body
homeostasis, preventing dehydration and loss of essential minerals.
The topical route has a number of advantages over oral and
parenteral routes: no first-pass metabolism, greater convenience
resulting in better treatment compliance, lower side-effect
frequency, and prompt dosing cessation if required. However, the
stratum corneum allows penetration of only 1 to 5% of substances
applied topically, making this application route much less
efficient. Lipophilic and small molecules (up to 500 Da) can cross
the stratum corneum, since keratinocytes are covered by a lipid
matrix, while it is virtually impossible for hydrophilic and large
drugs to cross intact, normal skin, which means that passive
topical delivery is restricted. To address this, techniques have
been developed aimed at optimizing drug skin penetration by means
of chemical, mechanical and physical methods, such as adding
permeating active agents and using occlusion, iontophoresis,
microneedling, lasers and intense pulsed light, and it is now
possible to deliver medication to different skin layers or
transdermally to the systemic circulation. Drug delivery is a hot
topic in dermatology, with a Pubmed search generating 203431
articles. Offering a detailed review of this emerging therapeutic
option, including the various methods available, this unique book
guides physicians and doctors in selecting the correct
technologies, technique and products for each patient.
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