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Xenobiotic Metabolic Enzymes: Bioactivation and Antioxidant Defense (Paperback, 1st ed. 2020)
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Xenobiotic Metabolic Enzymes: Bioactivation and Antioxidant Defense (Paperback, 1st ed. 2020)
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This book provides a comprehensive, organized, and concise overview
of xenobiotic metabolic enzymes and their health implications. The
subjects addressed are broad in scope with an emphasis on recent
advances in research on biochemical and biomedical aspects of these
enzymes. The xenobiotics discussed include not just drugs, but also
food, smoke, and other environmental chemicals. The subjects
covered in this work include: metabolic enzymes and their catalyzed
reactions, reactive intermediates generated from metabolic
activation, oxidative stress mediated by electrophilic reactive
intermediates, bioactivation - mediated cellular and functional
damages, activation of Nrf2 - ARE pathway, genetic variations
affecting metabolic enzyme expression, enzyme polymorphisms
affecting xenobiotic - mediated toxicity, induction of metabolic
enzymes for health benefits, and a diversity of metabolic enzyme
modulators.
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