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Validation of Alternative Methods for Toxicity Testing (Paperback, Softcover reprint of the original 1st ed. 2016)
Loot Price: R6,405
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Validation of Alternative Methods for Toxicity Testing (Paperback, Softcover reprint of the original 1st ed. 2016)
Series: Advances in Experimental Medicine and Biology, 856
Expected to ship within 10 - 15 working days
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This book provides information on best practices and new thinking
regarding the validation of alternative methods for toxicity
testing. It covers the validation of experimental and computational
methods and integrated approaches to testing and assessment.
Validation strategies are discussed for methods employing the
latest technologies such as tissue-on-a-chip systems, stem cells
and transcriptomics, and for methods derived from pathway-based
concepts in toxicology. Validation of Alternative Methods for
Toxicity Testing is divided into two sections, in the first,
practical insights are given on the state-of-the-art and on
approaches that have resulted in successfully validated and
accepted alternative methods. The second section focuses on the
evolution of validation principles and practice that are necessary
to ensure fit-for-purpose validation that has the greatest impact
on international regulatory acceptance of alternative methods. In
this context validation needs to keep pace with the considerable
scientific advancements being made in toxicology, the availability
of sophisticated tools and techniques that can be applied in a
variety of ways, and the increasing societal and regulatory demands
for better safety assessment. This book will be a useful resource
for scientists in the field of toxicology, both from industry and
academia, developing new test methods, strategies or techniques, as
well as Governmental and regulatory authorities interested in
understanding the principles and practicalities of validation of
alternative methods for toxicity testing.
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