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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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Mucosal Immune Defense: Immunoglobulin A (Hardcover, 2007 ed.)
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Mucosal Immune Defense: Immunoglobulin A (Hardcover, 2007 ed.)
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Immune responses at mucosal surfaces play a major role in host
mucosal defense against microbial pathogens and in the pathogenesis
of acute and chronic mucosal inflammatory diseases. immunogenetic
approaches in combination with human and murine in vitro cell
culture and in vivo model systems to address questions in mucosal
immunity. Humans produce more immunoglobulin A (IgA) than all other
antibody isotypes combined, most of which is rapidly transported
into the external secretions bathing mucous membranes. It has been
estimated that more than 3 grams of IgA are transported daily into
mucosal secretions, carrying out a wide range of antimicrobial and
anti-inflammatory functions. IgA is the second most abundant class
of antibody in the bloodstream, contributing to systemic as well as
secretory immunity. Recent advances in human genomics, gene
regulation, structural biology, cell signaling, and immunobiology
have greatly enhanced our understanding of this important class of
antibody. knowledge of the biology of IgA, including structure of
IgA and its interaction with Fc receptors; epithelial transport of
IgA; regulation of the mucosal IgA system; biological roles of IgA,
including newly discovered functions; IgA-associated diseases, and
therapeutic applications for IgA. Chapters have been contributed by
internationally recognized leaders in the field of IgA research,
representing 8 countries on 3 continents.
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