In India, cardiovascular diseases (CVDs) are estimated to be
responsible for 1.5 million deaths annually. Indeed, it is
estimated that by 2020, CVDs will be the largest cause of mortality
and morbidity in India. Hypertension is a major risk factor for
CVDs, including stroke and myocardial infarction, and its burden is
increasing disproportionately in developing countries. It is
estimated that around two-thirds of those with people with
hypertension worldwide were living in developing countries (639
million) in 2000, and that this would rise to three-quarters living
in developing countries (1.15 billion) by 2025. Uric acid builds up
when the body makes too much of it, fails to excrete it or both. It
is a metabolic product resulting from purine. It remains possible
that uric acid is a marker for xanthine oxidase-associated oxidants
and that the latter could be driving the hypertensive response.
However, the evidence suggests that uric acid is a true modifying
and possibly causal factor for human primary hypertension. Hence,
early management of hyperuricemia might delay the development of
essential hypertension.
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