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Heat Shock Proteins in Neural Cells (Paperback, 2009)
Loot Price: R4,504
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Heat Shock Proteins in Neural Cells (Paperback, 2009)
Series: Neuroscience Intelligence Unit
Expected to ship within 10 - 15 working days
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eat shock proteins (HSPs), also called stress proteins, are not
only induced in response to elevated temperatures, but also as a
result of various stress situations, including environmental
strains, viral H infection, ischemia, anoxia and oxidative stress.
These stress situations trigger cellular defence mechanisms that
act as an emergency system capable of combatting the toxic
consequences due to the accumulation of misfolded proteins. Heat
shock proteins are involved in many physiological processes,
including development and differentiation, organisation of the
cytoarchi tecture by binding to cytoskeletal elements and
regulation of the balance between cell death and survival. Many
heat shock proteins work as molecular chaperones. In this role,
they contribute to in vivo protein folding and prevent
nonproductive interactions with other proteins and cellular c-
ponents. In recent years it has been found that the chaperone
system and the proteolytic machinery work closely together, and
that proteasomal - hibition causes the upregulation of stress
proteins. Impairment of the proteasomal machinery and chaperone
functions lead to protein damage, which contributes to
neurodegenerative disorders and to the aging process.
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