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Autophagy in Mammalian Systems, Part B, Volume 452 (Hardcover, 452nd edition)
Loot Price: R5,140
Discovery Miles 51 400
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Autophagy in Mammalian Systems, Part B, Volume 452 (Hardcover, 452nd edition)
Series: Methods in Enzymology
Expected to ship within 12 - 17 working days
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This is the companion volume to Daniel Klionsky s "Autophagy: Lower
Eukaryotes, " which features the basic methods in autophagy
covering yeasts and alternative fungi (aspergillus, podospora,
magnaporthe). Klionsky is one of the leading authorities in the
field. He is the editor-in-chief of "Autophagy." The November 2007
issue of "Nature Reviews" highlighted his article, Autophagy: From
phenomenology to molecular understanding in less than a decade. He
is currently editing guidelines for the field, with 230
contributing authors, that will publish in "Autophagy."
Particularly in times of stress, like starvation and disease,
higher organisms have an internal mechanism in their cells for
chewing up and recycling parts of themselves. The process of
internal house cleaning in the cell is called autophagy - literally
self-eating. Breakthroughs in understanding the molecular basis of
autophagy came after the cloning of ATG1 (autophagy-related gene 1)
in yeast. (To date, 30 additional yeast genes have been
identified.) These ATG genes in yeast were the stepping stones to
the explosion of research into the molecular analysis of autophagy
in higher eukaryotes. In the future, this research will help to
design clinical approaches that can turn on autophagy and halt
tumor growth."
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