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Autophagy: Lower Eukaryotes and Non-Mammalian Systems, Part A, Volume 451 (Hardcover, 451st edition)
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Autophagy: Lower Eukaryotes and Non-Mammalian Systems, Part A, Volume 451 (Hardcover, 451st edition)
Series: Methods in Enzymology
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This is the companion volume to Daniel Klionsky's "Autophagy: Lower
Eukaryotes," which features the basic methods in autophagy covering
yeasts and alternative fungi (aspergillus, podospora, magnaporthe).
Klionsky is one of the leading authorities in the field. He is the
editor-in-chief of "Autophagy," The November 2007 issue of "Nature
Reviews" highlighted his article, "Autophagy: from phenomenology to
molecular understanding in less than a decade." He is currently
editing guidelines for the field, with 230 contributing authors,
that will publish in "Autophagy,"
Particularly in times of stress, like starvation and disease,
higher organisms have an internal mechanism in their cells for
chewing up and recycling parts of themselves. The process of
internal "house-cleaning" in the cell is called autophagy -
literally self-eating. Breakthroughs in understanding the molecular
basis of autophagy came after the cloning of ATG1
(autophagy-related gene 1) in yeast. (To date, 30 additional yeast
genes have been identified.) These ATG genes in yeast were the
stepping stones to the explosion of research into the molecular
analysis of autophagy in higher eukaryotes. In the future, this
research will help to design clinical approaches that can turn on
autophagy and halt tumor growth.
*Establishes the functional roles of specific cellular proteins in
selective and nonselective autophagy in mammalian cells which aids
researchers in determining why autophagy is shut down in neoplastia
(growth of abnormal tissue mass) and turned on during bacterial
invasion.
*Includes methods to evaluate the role of autophagy in the
drug-induced cell death of cancer cells in culture, which helps
researchersdesign clinical approaches that can turn on autophagy
and halt tumor growth.
*Covers higher eukaryotes including lifespan in C. elegans to
marine organisims and bridging into the clinical aspects, including
autophagy in chronic myelogenous leukemia (CML is one of four types
of leukaemia), lung cancer, prostate cancer, and cardiac cells.
General
Imprint: |
Academic Press Inc
|
Country of origin: |
United States |
Series: |
Methods in Enzymology |
Release date: |
December 2008 |
First published: |
December 2008 |
Volume editors: |
Daniel Klionsky
|
Dimensions: |
229 x 152 x 46mm (L x W x T) |
Format: |
Hardcover
|
Pages: |
808 |
Edition: |
451st edition |
ISBN-13: |
978-0-12-374548-4 |
Categories: |
Books >
Science & Mathematics >
Biology, life sciences >
Cellular biology >
General
|
LSN: |
0-12-374548-9 |
Barcode: |
9780123745484 |
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