Facilitating the innovation, development, and application of new
spectroscopic methods in proteomics, Spectral Techniques in
Proteomics provides a broad overview of the spectroscopic toolbox
that can be used, either with proteome or sub-proteome mixtures or
with individual/purified proteins studied in parallel. It gives a
modest overview of existing and proven techniques as well as a
detailed examination of less established spectroscopic methods with
studied speculation on future applications.
Intended for a broad audience of protein biochemists and
biophysicists, the book adopts a wider definition of proteomics to
include the systems-based study of proteomes and sub-proteomes
involving proteins related through regulatory cascades, metabolic
pathways, post-translational modifications, or associated biologic
effect, as well as the parallel study of subsets such as proteins
with associated protein folds (structural proteomics) or binding
sites (chemical proteomics). Beginning by defining thescope of the
field as is relevant to spectroscopists, the book then briefly
reviews current commonly used spectroscopic methods. It covers
separation techniques that typically precede ESI studies as well as
MALDI MS/MS based protein identification. SELDI is also presented
as a tool that combines separation techniques with MS analysis on
the same chip. The book presents studies of protein-protein and
protein-ligand interactions using NIR fluorescence, NMR, MS, and
SPR. Recent developments in ICAT labeling strategies are addressed
along with a discussion of metabolomics. A description of advances
in structural proteomics using NMR, x-ray crystallography, and EPR
precedes a final summary of currenttechnology and future prospects
of the science.
Analyzing the current state of the science and the future
evolution of the field, Spectral Techniques in Proteomics applies a
systems-based approach to studying the function and mechanism of
proteins.
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