Ultradian rhythms play an essential part at all levels of
biological organization, providing timekeeping for intracellular
processes, playing various roles in intracellular signalling
systems and underpinning coherent behaviour in tissues and organs.
They are crucial to endocrine and neural performance and in
psychobiology. This book brings together the evidence for these
findings. In lower eukaryotes short-period rhythms (period 30-70
min) are coupled to an ultradian clock which serves as a central
timekeeper. In metazoans, similar rhythms are necessary for
intercell communications, and temporal coupling for the
coordination of integrated functions of tissues and organs to
provide "homeodynamics" of the whole organism. Electrical,
endocrine and behavioural rhythms characterize both wakefulness and
sleep; pathologically disordered states give rise to dynamic
diseases. Chapters on human movements, sleep, attention span and
alertness indicate the broad span of this subject. A continuum can
now be traced from the molecular genetic, through the cellular and
neuroendocrine to the behavioural and psychosocial levels. Many of
the results presented in this book are recent and novel, and have
far-reaching consequences for our understanding of health and
disease.
Our first book (published 15 years ago) ended with" Epilogue:
The Unification Hypothesis of Chronobiology-Psychobiology from
Molecule to Mind." In retrospect we can now recognise how this
epilogue was a prescient vision of what is now the cutting edge of
epigenetics, bioinformatics, systems biology, neuroscience, and the
new sciences of consciousness that are the foundation for the
emerging vision of life and philosophy in ourcurrent era. Each of
the four parts of this book are successive iterations towards this
new integration of the life sciences from molecule to mind and
spirit in the emergent ethos of the future.
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