A new class of fluorescent labels has been produced by conjugating
water soluble quantum dots (QDs) with biomolecules. Quantum Dots
(QDs) are semiconductor nanocrystals (1 10 nm) exhibiting
distinctive photoluminescence (PL) properties due to the quantum
confinement effect. The resultant nanoprobes can potentially
overcome many of the functional limitations encountered with
organic dyes. High-quality quantum dots are highly stable against
photobleaching and have narrow, symmetric emission spectra. In
particular, the emission wavelength of quantum dots can be
continuously tuned by simply changing the particle size, and a
single light source can be used for simultaneously excitation of
all different-colored dots. These novel optical properties can
render quantum dots ideal fluorophores for sensitive, Multicolor
and multiplexing applications in molecular biology and
bioengineering.
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