Laminins are major proteins in the basal lamina (one of the layers
of the basement membrane), a protein network foundation for most
cells and organs. Laminins are an important and biologically active
part of the basal lamina, influencing cell differentiation,
migration, and adhesion, as well as phenotype and survival. In this
book, the authors present current research in the study of the
structure, biological activity and role in disease of laminins.
Topics include the key roles of laminins from embryos to adult
skeletal muscle; Laminin-332 and integrins; anosmin-1 and
galectin-1 as laminin interactors in nervous system development and
pathology; loss of laminin alpha two; role of laminin in epithelial
morphogenesis in the liver; laminins in uterine remodelling and
embryo development during pregnancy; human gingival laminin-332
degradation by oral bacteria; and laminins as a modulator of the
axonal response to guidance cues.
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