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Growth Factors & Epilepsy (Hardcover, Illustrated Ed)
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Growth Factors & Epilepsy (Hardcover, Illustrated Ed)
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The discovery that a variety of growth factors modulate
excitability in the adult brain, and that the expression of growth
factors and their receptors are often modulated by seizure
activity, has opened an exciting new chapter in epilepsy research.
Recent findings shed new light on these and other ways growth
factor neurobiology impacts epilepsy research, including the role
of growth factors in seizure-induced neurogenesis, kindling, and
morphological changes that contribute to the epileptic phenotype.
In addition to neurotrophins such as brain-derived neurotrophic
factor, and the p75 and trk receptors for neurotrophins, recent
studies also implicate vascular endothelial growth factor (VEGF),
basic fibroblast growth factor (bFGF), and glial cell line-derived
neurotrophic factor (GDNF) in seizure-induced structural and
functional changes. The current volume highlights seminal
contributions to this field by renowned scientists in both the
growth factor and epilepsy research fields.
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