An authoritative review of the current state-of-the-art
understanding of the structure and function of the adrenergic
receptor subtypes, as well as of the role played by these receptors
in physiological and pathophysiological settings. Topics range from
structure-function studies and the imaging of adrenergic receptors
to the use of genetically altered mouse models and
pharmacogenomics. Highlights include a survey of the knockout and
overexpressed mouse models, a review of the new ways that
adrenergic receptors can signal, and the effects of polymorphisms
on clinical outcomes and on potential gene therapy applications.
The side-by-side comparison of all the adrenergic receptors (a1,
a2, and b) provides the reader with an excellent survey of the
field, including the rationale for designing better drugs to
control blood pressure and heart function.
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