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Antiulcer Screening of Selected Plants of Plumbago Species and the Effect of Plumbagin in Gastric Cell Lines - Studies of Plumbago Plants for Ulcer and Inflammation Treatment (Paperback)
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Antiulcer Screening of Selected Plants of Plumbago Species and the Effect of Plumbagin in Gastric Cell Lines - Studies of Plumbago Plants for Ulcer and Inflammation Treatment (Paperback)
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Master's Thesis from the year 2012 in the subject Medicine -
Pharmacology, course: Masters in Pharmacy, language: English,
abstract: ANTIULCER SCREENING OF SELECTED PLANTS OF PLUMBAGO
SPECIES & THE EFFECT OF PLUMBAGIN IN GASTRIC CELL LINES
Objectives: The objective of the study is to evaluate the antiulcer
effect of the Plumbago species and to investigate the most
effective plant among the selected Plumbaginales, P.auriculata,
P.indica & P.zeylanica after the nvitro evaluation. Materials
and Methods: MTT assay was used to perform the cytotoxic effect of
the Plumbagin and to scrutinize the least cytotoxic among the
Plumbaginales for gastroprotective effect. The DPPH scavenging
assay, Lipid peroxidase inhibition assay, Acid neutralising
capacity test and Ethanol induced ulcer model were used for
assessing the antiulcer effective plant for invivo studies.
Ranitidine (20mg/kg, p.o) was used as reference drug in the study.
Results and Discussion: MTT results revealed that the Plumbagin
showed cytotoxic activity at 40.18 g/ml, P.auriculata is having
least cytotoxic effect. Even though significant antiulcer activity
were exhibited by all the Plumbaginales and Plumbagin showed
significant antioxidant and acid neutralising assays, P.auriculata
had decreased the number of ulcers and increased in the percentage
gastric protection. Conclusion: P.auriculata showed antiulcer study
and the results were compared by Plumbagin, P.indica and
P.zeylanica. A future prospect on mechanism based studies and
isolation of the constituents is needed for the individual plants."
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