Human Airway Inflammation - Sampling Techniques and Analytical Protocols (Paperback, Softcover reprint of the original 1st ed. 2001)

Rubor (redness), tumor (swelling), calor (heat), and dolor (pain) are the classical signs of inflammation. These features are obvious in the skin, where injury or disease causes flare, wheal, and painful burning sensations. Vasodi- tation underlies the flare and heat, plasma exudation the swelling, and acti- tion of sensory nerves relays pain. In chronic conditions, skin biopsies show inflammatory cell infiltrate. Inflammation is not unique to the skin and contr- utes to disease and repair processes in other organ systems in the body. From the viewpoint of this volume, lung inflammation is now recognized as central to the pathophysiology of a number of severe respiratory conditions, the two most common being asthma and chronic obstructive pulmonary disease (COPD). In asthma, and to a lesser extent COPD, there is evidence of vasodilatation, with congestion of blood vessels accompanied by reddening of the airway mucosa, and of plasma exudation, leading to swelling of the airway wall. Similarly, although less pronounced than in the skin, there is evidence of pain, for example, the - pleasant chest sensations associated with asthma attacks. Understanding the pat- genesis of airway inflammation will enable rational design of drugs to effectively treat conditions such as asthma and COPD. However, whereas immediate access to the skin facilitates investigation of disease processes, the lung, although "open to atmosphere," is much less accessible. Consequently, the investigation of lung inflammation is usually indirect. Thus, a wide variety of research techniques are used.

General

Imprint:	HumanaPress
Country of origin:	United States
Series:	Methods in Molecular Medicine, 56
Release date:	August 2014
First published:	2001
Editors:	Duncan F. Rogers • Louise E. Donnelly
Dimensions:	229 x 152 x 24mm (L x W x T)
Format:	Paperback
Pages:	440
Edition:	Softcover reprint of the original 1st ed. 2001
ISBN-13:	978-1-4899-4372-9
Categories:	Books > Medicine > Clinical & internal medicine > Respiratory medicine
LSN:	1-4899-4372-2
Barcode:	9781489943729

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