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Advances in Perinatal Medicine - Volume 5 (Paperback, Softcover reprint of the original 1st ed. 1986)
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Advances in Perinatal Medicine - Volume 5 (Paperback, Softcover reprint of the original 1st ed. 1986)
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The state of health care is reflected by perinatal and neonatal
morbidity and mortality as well as by the frequencies of long-term
neurologic and developmental disorders. Many factors, some without
immediately rec ognizable significance to childbearing and many
still unknown, undoubt edly contribute beneficially or adversely to
the outcome of pregnancy. Knowledge concerning the impact of such
factors on the fetus and sur viving infant is critical. Confounding
analyses of pregnancy outcome, especially these past two or three
decades, are the effects of newly un dertaken invasive or inactive
therapeutic approaches coupled with the advent of high technology.
Many innovations have been introduced with out serious efforts to
evaluate their impact prospectively and objectively. The
consequences of therapeutic misadventures characterized the past;
it seems they have been replaced to a degree by some of the
complications of applied technology. Examples abound: after overuse
of oxygen was recognized to cause retrolental fibroplasia, its
restriction led to an in crease in both neonatal death rates and
neurologic damage in surviving infants. Administration of vitamin K
to prevent neonatal hemorrhagic disease, particularly when given in
what we now know as excessive dos age, occasionally resulted in
kernicterus. Prophylactic sulfonamide use had a similar end result.
More recent is the observation of bronchopul monary dysplasia as a
complication of respirator therapy for hyaline membrane disease."
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