This invaluable reference presents a comprehensive review of the
basic methods for characterizing bioadhesive materials and
improving vehicle targeting and uptake-offering possibilities for
reformulating existing compounds to create new pharmaceuticals at
lower development costs.
Evaluates the unique carrier characteristics of bioadhesive
polymers and their power to enhance localization of delivered
agents, local bioavailability, and drug absorption and transport
Written by over 50 international experts and reflecting broad
knowledge of both traditional bioadhesive strategies and novel
clinical applications, Bioadhesive Drug Delivery Systems
discusses mechanical and chemical bonding, polymer-mucus
interactions, the effect of surface energy in bioadhesion, polymer
hydration, and mucus rheology
analyzes biochemical properties of mucus and glycoproteins, cell
adhesion molecules, and cellular interaction with two- and
three-dimensional surfaces
covers microbalances and magnetic force transducers, atomic force
microscopy, direct measurements of molecular level adhesions, and
methods to measure cell-cell interactions
examines bioadhesive carriers, diffusion or penetration enhancers,
and lectin-targeted vehicles
describes vaginal, nasal, buccal, ocular, and transdermal drug
delivery
reviews bioadhesive interactions with the mucosal tissues of the
eye and mouth, and those in the respiratory, urinary, and
gastrointestinal tracts
explores issues of product development, clinical testing, and
production
and more
Amply referenced with over 1400 bibliographic citations, and
illustrated with more than 300 drawings, photographs, tables, and
display equations, Bioadhesive Drug Delivery Systems serves as a
sound basis for innovation in bioadhesive systems and an excellent
introduction to the subject. This unique reference is ideal for
pharmaceutical scientists and technologists; chemical, polymer, and
plastics engineers; biochemists; physical, surface, and colloid
chemists; biologists; and upper-level undergraduate and graduate
students in these disciplines.
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