Mathematical Modelling of the Cell Cycle Stress Response (Hardcover, 2014 ed.)

The cell cycle is a sequence of biochemical events that are controlled by complex but robust molecular machinery. This enables cells to achieve accurate self-reproduction under a broad range of conditions. Environmental changes are transmitted by molecular signaling networks, which coordinate their actions with the cell cycle. This work presents the first description of two complementary computational models describing the influence of osmotic stress on the entire cell cycle of S. cerevisiae. Our models condense a vast amount of experimental evidence on the interaction of the cell cycle network components with the osmotic stress pathway. Importantly, it is only by considering the entire cell cycle that we are able to make a series of novel predictions which emerge from the coupling between the molecular components of different cell cycle phases. The model-based predictions are supported by experiments in S. cerevisiae and, moreover, have recently been observed in other eukaryotes. Furthermore our models reveal the mechanisms that emerge as a result of the interaction between the cell cycle and stress response networks.

General

Imprint:	Springer International Publishing AG
Country of origin:	Switzerland
Series:	Springer Theses
Release date:	October 2013
First published:	2014
Authors:	Elahe Radmaneshfar
Dimensions:	235 x 155 x 13mm (L x W x T)
Format:	Hardcover
Pages:	109
Edition:	2014 ed.
ISBN-13:	978-3-319-00743-4
Categories:	Books > Science & Mathematics > Mathematics > Applied mathematics > Mathematical modelling Books > Science & Mathematics > Physics > Applied physics & special topics > Biophysics Books > Science & Mathematics > Biology, life sciences > Cellular biology > General Promotions
LSN:	3-319-00743-2
Barcode:	9783319007434

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