Communication between cells via intercellular channels gap
junctions appears essential to certain developmental processes and
appropriate organ function. Gap Junctions in Development and
Disease aims to describe the molecular events underlying impaired
development and disease. Beginning with a comprehensive review of
various mouse and human genes encoding the channel-forming
connexins, later chapters describe several connexin mutations
associated with human diseases such as hereditary deafness and
female infertility. Erroneous signaling mediated by the interaction
of mutant connexins with other proteins, thought to be responsible
for dysfunction of organs such as heart, muscle, brain, skin, lens,
placenta, and endocrine tissue in both mice and men, is also
addressed.
Although the question of why some mutations in gap-junction
proteins lead to specific phenotypes remains to be answered, the
reviews in this book provide an intriguing insight into the future
direction of this research field."
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