The Subthalamic Nucleus - Part I: Development, Cytology, Topography and Connections (Paperback, 2008 ed.)

1 Introduction 1.1 Hemiballism Hemiballism or hemichorea is a rare neurological disorder, but the crucial invol- ment of the subthalamic nucleus (STN) in its pathophysiology has been app- ciated for decades (Jakob 1923; Martin 1927; Glees and Wall 1946; Whittier and Mettler 1949; Carpenter and Carpenter 1951; Crossman 1987). Only recently have serious doubts come forward. Postuma and Lang (2003) have described the STN as being involved in only a minority of cases, and indicated unrecognized causes such as non-ketotic hyperosmolar hyperglycaemia and complications of human immunodeficiency virus (HIV) infections. Moreover, the crucial involvement of a lesion of the STN is in doubt (Guridi and Obeso 2001; Postuma and Lang 2003). On the other hand, idiopathic Parkinson's disease (Battistin et al. 1996; Usunoff et al. 2002) is a common neurodegenerative disorder, but the key role of the STN in the pathophysiological origin of the parkinsonian state has become evident only recently (Miller and DeLong 1987; Mitchell et al. 1989; Bergman et al. 1990, 1994; Hollerman and Grace 1992; Guridi et al. 1993; Parent and Hazrati 1995b; Hassani et al. 1996; Levy et al. 1997, 2002; Blandini et al. 2000; Hirsch et al. 2000; Ni et al.

General

Imprint:	Springer-Verlag
Country of origin:	Germany
Series:	Advances in Anatomy, Embryology and Cell Biology, 198
Release date:	July 2008
First published:	2008
Authors:	Enrico Marani • Tjitske Heida • Egbert A. J. F. Lakke • Kamen G. Usunoff
Dimensions:	235 x 155 x 8mm (L x W x T)
Format:	Paperback
Pages:	117
Edition:	2008 ed.
ISBN-13:	978-3-540-79459-2
Categories:	Books > Science & Mathematics > Biology, life sciences > Cellular biology > General
LSN:	3-540-79459-X
Barcode:	9783540794592

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