This monograph highlights modern concepts of brain ischemia and
strategies of neuroprotective therapy. The first part of the book
is devoted to mechanisms of ischemic brain damage. The authors
present the results of their own clinical and experimental studies
conducted in the last two decades, as well as the achievements of
native and foreign neurological researches that open a new stage in
understanding how reversible changes of blood flow and metabolism
are transformed into a permanent morphological lesion, i.e. brain
infarction. The most important advances in areas of ischemic energy
failure, main mechanisms of the glutamate-calcium cascade,
influence of metabolic acidosis on ischemic damage, delayed
neuronal death connected with microglial activation, local
inflammation, autoimmune reactions, trophic dysfunction, and
apoptosis, as well as of reaction of the stress-mediating endocrine
system to focal brain ischemia are shown in animals and humans, and
the relevant literature is cited and critiqued. The book also
explores topics that recently have experienced substantial growth,
such as gene expression and subsequent molecular events in response
to acute brain ischemia, connected with both tissue damage and
reparation. The authors demonstrate not only universal features of
the process of brain ischemia, but also individual peculiarities of
its course in patients and analyse their reasons.
The modern strategies of neuroprotective therapy are disclosed
in the second part of the book. The review of main neuroprotectors'
studies performed under both experimental (in vitro and in vivo)
and clinical conditions, as well as results of the authors' own
investigations of original Russianneuroprotectors are
presented.
The book's balanced demonstration of progress in the field of
fundamental researches in patients with ischemic stroke and in
experimental models of acute brain ischemia is valuable for
clinicians (neurologists, cardiologists, neurosurgeons), as well as
for basic scientists and research trainees.
General
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