Well-respected leaders in the field of in vitro neurotoxicology
take a fresh look at their own and other's work, critically and
comparatively analyzing it across experimental systems and
toxicants, and synthesizing essential principles for in vitro
neurotoxicity testing. Neurotoxicants of significance to human
health are emphasized, especially those for which metabolism and
dose-responses are well well studied both in vivo and in vitro:
lead, mercury, organophosphorous insecticides, polychlorinated
biphenyls and dioxin, ethanol, and endogenous proteins. The goal is
to set out new concepts and research directions that will hasten
significant improvement in the methods and systems for in vitro
neurotoxicity testing.
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