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Chemical Recognition in Biology (Paperback, Softcover reprint of the original 1st ed. 1980)
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Chemical Recognition in Biology (Paperback, Softcover reprint of the original 1st ed. 1980)
Series: Molecular Biology, Biochemistry and Biophysics Molekularbiologie, Biochemie und Biophysik, 32
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Studies of chemical recognition in biology were initiated about
half a century ago with the flrst kinetic data obtained on enzyme
catalysis and inhibition. They led to a rather static
representation of the recognition process illustrated by the lock
and key model that still continues to influence our overall image
of recognition and its specificity. In several cases,
crystallographic studies of enzyme-substrate complexes have
supported this model. Indeed, in a crystallized ligand-enzyme
complex, a close fltting is observed between the active center of
the enzyme and the functional groups of the ligand. How ever, this
does not necessarily result from a direct recognition process
between rigid structures, but may result from a progressive
adaptation during which the initial struc tures of the enzyme and
the ligand are modified (induced-flt mechanism). Recently, a great
deal of work has been devoted to the study of recognition in more
complex systems such as the replication or the translation machin
ries; clearly, the extraordinary precision of such systems cannot
be explained solely in terms of physical matching between enzymes
and their substrates. This has led to a noticeable change of
perspective in these areas. As a result of the new kinetic
viewpoint, one rather focuses on the time-course of the processes,
on the kinetic balance between steps of the reaction, on the
energy-accuracy relationships and on the strategies which permit
the achievement of high precision using relatively error-prone
components in an appropriate dynamic interplay."
General
Imprint: |
Springer-Verlag
|
Country of origin: |
Germany |
Series: |
Molecular Biology, Biochemistry and Biophysics Molekularbiologie, Biochemie und Biophysik, 32 |
Release date: |
December 2011 |
First published: |
1980 |
Editors: |
F. Chapeville
• A.L. Haenni
|
Dimensions: |
244 x 170 x 22mm (L x W x T) |
Format: |
Paperback
|
Pages: |
430 |
Edition: |
Softcover reprint of the original 1st ed. 1980 |
ISBN-13: |
978-3-642-81505-8 |
Categories: |
Books >
Science & Mathematics >
Biology, life sciences >
Zoology & animal sciences >
General
|
LSN: |
3-642-81505-7 |
Barcode: |
9783642815058 |
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